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More harm than good. However, rather than creating a specific reward, Dreams understood the importance of building a thriving community and showcasing their artistic contributions. Through categories dedicated to different genres and artistic mediums — as well as regularly hosted competitions, award shows and expos — Media Molecule has repeatedly brought users together and consistently encouraged their creativity. By prioritizing these elements that Project Spark lacked, Dreams has successfully evolved into a massive social platform for both experienced artists and aspiring creators. Unfortunately, Media Molecule will end its live support for Dreams on September 1st, meaning the game won't receive any more content updates or community events. It's a huge blow to the platform, especially since these features have kept it active for the past few years. However, this doesn't necessarily mean the end for Dreams. Unlike Project Spark, Dreams has survived purely on its community's passion for creating and sharing their work. If Media Molecule upholds their promise to keep Dreams' servers online with bug-fixes and minor updates, its community can keep the game alive for years to come.

Quality assessment tools, chemical molecule drawing tools, etc. assist in preparing the molecules for docking. Rapid advance in the development of reliable computational docking tools, docking web servers contribute to solve the unknown problems by docking study between different types of molecules or atoms or ions interacting with each other. Chen has listed down docking databases and webservers in their review [6]. Although there are many accurate reliable docking algorithms emerging, limitations and challenges are still there because of imperfections in their scoring functions, handling protein flexibility, explicit water, etc. Docking software can be evaluated and their limitations can be overcome by benchmark testing with Critical Assessment of PRediction of Interactions (CAPRI) [7]. Various types of databases, software programs, and web servers used in different steps in the docking technique are listed in Table 1.Table 1 List of databases, software programs and web servers used in different steps in docking methodFull size tableMolecules used in docking studies and binding energy calculationWhen two molecules, in close proximity, favorably interact with each other, they bind to form a stable complex. The acceptor molecule is termed a receptor or target or macromolecule (though it is bigger in size compared to the second molecule) and the received molecule by the receptor is termed a ligand. The site where binding happens is known as the active site or binding site or binding pocket. The stable complex formed is termed a receptor-ligand complex as shown in Fig. 1. There are many different types of noncovalent interaction forces that cause the receptor and ligand to bind together to form a stable complex. Those are torsional, hydrophilic, hydrophobic, van der Waals, electrostatic, hydrogen-bonding, and desolvation, etc. So, the main goal was to find the most stable receptor-ligand complex with optimized geometry and minimum binding energy.Fig. 1Receptor-ligand docked complex. Docking of a small molecule “Ligand” (cyan) to a bigger size molecule “Receptor” (yellow) to produce a stable docked complex. (Color figure online)Full size imageThe energy score and energy terms of binding pose are calculated using scoring functions. The ongoing scoring functions applied in different docking algorithms are of four

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